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LSI Medience Corp.

LSI Medience Corp. 는 1975년부터 시작하여 일본 비임상시험에서
시장을 선도하는 업체입니다.


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LSI Medience Corp. 는 1975년 창업을 시작하였고 약 3500명의 직원, 자본금 30억엔의 기업입니다.

LSI Safety Institute Corp.

LSIM Safety Institute Corp. 는 LSI Medience Corp. 에서 100%
분사화 한 비임상시험 전문 기업입니다.


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Kashima Lab

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STUDY MENU

General Toxicology

  • Single dose toxicity (Mouse / Rat / Dog / Monkey / Minipig)
  • Repeated dose toxicity (Mouse / Rat / Dog / Monkey / Minipig)
  • Carcinogenicity including Tg animals
  • Juvenile toxicity
  • Reprocuctive and developmental toxicity
  • Inhalation toxicity
  • Genotixicity (Ames / In vitro chromosomal aberration test / In vitro micronucleus test / micronucleus test / Comet assay etc.)
  • Skin / Ocular irritation
  • Phototoxicity
  • Toxicokinetics(TK)
  • Homonal activity assay
  • SEND (Standard for the exchange fo nonclinical data)

    • Safety Phamacology Core Battery

  • Central nervous system
  • Cardiovascular system
  • Respiratory system

    • DMPK

  • Absorption/Distribution/Metabolism/Excertion(ADME)
  • Pharmacokinetics
  • QWBA(Quantitative whole body autoradiography)
  • Bile excretion and enterohepatic circulation(free-moving method)
  • Placental/Fatal transfer/Milk secretion
  • Pharmacokinetic in diseasemodel animals
  • In vivo metabolite profiling and identification
  • in vitro metabolite profiling and identification(Microsomes/Hepatocytes,etc.)
  • Plasma protein binding / Blood cell distribution(In vivo / In vitro)
  • CYP and UGT inhibition
  • CYP and UGT isoform identification
  • In vitro human CYP induction
  • Transporter inhibition and substrate recognition
  • In vitro digestive tract absorption(Caco-2)
  • In vitro skin permeability
  • In vitro covalent binding

    • Phamacology

  • Central Nervous System (Pain / Learning / Stress / etc.)
  • Circulatory System (Hypertention / Arrhythmia / Peripheral blood flow / etc.)
  • Respiratory System (Asthma / Conjunctivitis / Pulmonary fibrosis)
  • Digestive System (Peptic Ulcer / Gastrointestinal motility / Hepatopathy / etc.)
  • Renal and urinary system (Nephritis / Bladder pain)
  • Glycometabolism and lipid metabolism
  • Blood system
  • Inflammatory and allergy
  • Immune system (immunosuppression)
  • Skin
  • Tumor
  • Infectious disease
  • In vitro (Cytotoxicity study using primary cell culture / Tumor / Apoptisis / Inflammatiry Central Nervous System / Skin (Whitening ability Fibrosis) / etc.)
  • Regenreative theraphy (Myocadinal ischemia / Hind limb ischemia / Hepatopathy / Inflammatory and edema / Central ischemia / Pulmonary fibrosis / Nephritis / etc.)